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KMID : 0370220060500050338
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Yakhak Hoeji
2006 Volume.50 No. 5 p.338 ~ p.344
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Synthesis of Coumarin Analogues and their Antitumor Activity
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Lee Jee-Hyun
Kim Sung-Hoon
Lee Jae-Ho
Kim Hyun-Kwan
Kim Eui-Keom
Shen Gui-nan
Cho Soo-Hyun
Myung Chang-Seon
Kim Dong-Hee
Yun Mi-Young
Choi Yong-seok
Song Gyu-Yong
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Abstract
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A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-chloromethyl or 4-bromomethyl-6,7-dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.
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KEYWORD
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Crinum latifolium, coumarin, anti-angiogeneses, antitumor activity
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